Search results for "Anti-CD4 Monoclonal Antibody"

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Injection of donor-derived splenic dendritic cells plus a nondepleting anti-CD4 monoclonal antibody to prolong primary skin graft survival indefinite…

2010

Abstract We have previously shown that injection of donor-derived Fischer rat OX62+ dendritic cells plus an anti-CD4 monoclonal antibody generates donor-specific CD4+CD25+FoxP3+ regulatory T cells in Lewis rats spleens. The regulatory T cells indefinitely prolonged the survival of skin graft from Fischer rat and abrogated the antidonor antibody response. We have now shown that an injection of 2 × 10 6 donor-derived OX62+ dendritic cells plus 2 mg nondepleting anti-CD4 monoclonal antibody (W3/25) at 28 days before grafting induced indefinite skin graft survival in this combination; whereas an injection on day −1 prolonged it only to 50 days. This effect is donor specific. In both cases, we s…

Anti-CD4 Monoclonal Antibodymedicine.drug_classFischer ratMonoclonal antibodyMedicineAnimalsDonor derivedIL-2 receptorTransplantationbusiness.industryDonor specific antibodiesGraft SurvivalFOXP3Antibodies MonoclonalDendritic CellsSkin TransplantationMolecular biologyRats Inbred F344RatsRats Inbred LewImmunologyAntibody FormationCD4 AntigensSurgeryGraft survivalbusinessSpleenTransplantation proceedings
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In vitro study of alloreactivity and microchimerism after injection of dendritic cells and anti-CD4 monoclonal antibody in a combination of Lewis-Wis…

1998

Anti-CD4 Monoclonal Antibodymedicine.drug_classT-LymphocytesAntigen presentationRats Inbred WFBiologyMonoclonal antibodyLymphocyte ActivationImmune toleranceIsoantibodiesmedicineAnimalsTransplantation HomologousAntigen-presenting cellTransplantationTransplantation ChimeraAntibodies MonoclonalMicrochimerismDendritic cellDendritic CellsIn vitroRatsRats Inbred LewImmunologyCD4 AntigensCancer researchSurgeryTransplantation proceedings
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